What does TSCA §5 require?

The correct answer is pre-manufacture notification for new chemical substances, which is a fundamental provision of the Toxic Substances Control Act (TSCA) §5. This section requires manufacturers and importers to notify the Environmental Protection Agency (EPA) at least 90 days before manufacturing or importing a new chemical substance. The purpose of this notification is to allow the EPA to assess any potential risks associated with the new chemical before it enters the market. By doing so, the EPA can determine if the chemical poses an unreasonable risk to health or the environment and can take necessary regulatory actions.

In the context of other choices, post-manufacturing reporting typically pertains to established chemicals under different regulatory frameworks, while all chemicals being deemed hazardous is not accurate as TSCA distinguishes between new and existing substances and does not classify all as hazardous. Lastly, annual certification of chemical safety is a practice that may be required by other regulations or situations but does not specifically relate to TSCA §5's focus on new chemical substances. Therefore, the requirement for pre-manufacture notification is a critical regulatory mechanism aimed at ensuring safety and environmental protection before new chemicals are introduced.